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University of Queensland Diamantina Institute

Leukaemia Foundation Queensland Chair in Blood Cancer Research

Senior Staff Specialist, Department of Haematology, Princess Alexandra Hospital

Professor Maher Gandhi has established an international reputation studying immunity and identification of novel biomarkers in lymphoma. His research aims to understand the basis of lymphoma; to devise new treatments which are less toxic and more effective; to establish new biomarkers which will help determine the most effective treatment strategies and to monitor response and relapse and understand the development of lymphomas. Lymphomas studied include Hodgkin Lymphoma, PTLD, Diffuse Large B cell Lymphoma, Follicular Lymphoma and virus associated lymphomas. A broad range of approaches are utilised including genomics, molecular and cellular biology techniques and functional immunoassays.

Maher Gandhi received his medical degree in the UK in 1989, and then trained as a haematologist, including a Fellowship in malignant haematology at Princess Margaret Cancer Centre, Toronto. He obtained a PhD in immunology at Cambridge University. In 2003 he moved to Brisbane, working as a Senior Staff Specialist in the Haematology / Oncology Department of the Princess Alexandra Hospital, and established his own laboratory group at QIMR. He is Chair of Laboratory Sciences for the Australasian Leukaemia and Lymphoma Group, won the prestigious Australian Society of Medical Research Clinical Research Award in 2010 and in 2012 took up the inaugural John McCaffrey Cancer Council of Queensland / Office of Health and Medical Research Clinical Research Fellowship. He was privileged to serve as Chair of the Metro South Human Research Ethics Committee between 2011 2014. In 2013 he was appointed Professor of Experimental Haematology, University of Queensland, and took up his current role Head of the Blood Cancer Research Laboratory at the Diamantina Institute in 2014.

Recent treatment advances in Hodgkin Lymphoma: a concise review. Arulogun S, Hertzberg M, Gandhi MK. Intern Med J. 2016 Mar bvlgari mens fake ring 1. doi: 10.1111/imj.13051. [Epub ahead of print] Review. Jones, K., Wockner, L., Brennan, R. M., Keane, C., Chattopadhyay, P. K., Roederer, M., Price, D. A., Cole, D. K., Hassan, B., Beck, K., Gottlieb, D., Ritchie, D. S., Seymour, J. F., Vari, F., Crooks, P., Burrows, S. R. and Gandhi, M. K. (2016) The impact of HLA class I and EBV latency II antigen specific CD8+ T cells on the pathogenesis of EBV+ Hodgkin lymphoma. Clinical and Experimental Immunology, 183 2: 206 220. doi:10.1111/cei.12716

Leuk Lymphoma. 2016 Mar;57(3):507 8. doi: 10.3109/10428194.2015.1087522. Keane, Colm, Vari, Frank, Hertzberg, Mark, Le Cao, Kim Anh, Green, Michael R., Han, Erica, Seymour, John F., Hicks, Rodney J., Gill, Devinder, Crooks, Pauline, Gould, Clare, Jones, Kimberley, Griffiths, Lyn R., Talaulikar, Dipti, Jain, Sanjiv, Tobin, Josh and Gandhi, Maher K. (2015) Ratios of T cell immune eff ectors and checkpoint molecules as prognostic biomarkers in diff use large B cell lymphoma: a population based study. Lancet Haematology, 2 10: e445 e455.Scott, Linda M. and Gandhi, Maher K. (2015) Deregulated JAK/STAT signalling in lymphomagenesis, and its implications for the development of new targeted therapies. Blood Reviews, 29 6: 405 415. David M Kurtz; Michael R Green; Scott V Bratman; Florian P Scherer; Chih Long Liu; Christian Kunder; Kazuhiro Takahashi; Cynthia Glover; Colm Keane; Shingo Kihira; Brendan Visser; Jason Callahan; Katie Kong ; bvlgari fake engagement ring Malek Faham; Karen S Corbelli; David B Miklos; Ranjana Advani; Ronald Levy; Rodney J Hicks; Mark S Hertzberg; Robert S Ohgami; Maher K Gandhi; Maximilian Diehn; Ash A Alizadeh. Blood. Accepted 04/04/2015

HLA class I associations with EBV(+) post transplant lymphoproliferative disorder. Jones K, Wockner L, Thornton A, Gottlieb D, Ritchie DS, Seymour JF, Kumarasinghe G, Gandhi MK. Transpl Immunol. 2015 Mar;32(2):126 30.

Fine mapping of the 15q21 region implicate TP53BP1 and B2M in the lymphomagenesis of Follicular and Diffuse Large B Cell lymphomas. Carlos Aya Bonilla, Emily Camilleri, Miles Benton, Larisa M Haupt, Paula Marlton, Rod A Lea, Maher K Gandhi and Lyn R. Griffiths. Carcinogenesis Mutagenesis. 2014 May 21;15:390.

In silico analyses reveal common cellular pathways affected by loss of heterozygosity (LOH) events in the lymphomagenesis of Non Hodgkin's lymphoma (NHL). Carlos A Aya Bonilla, Emily Camiller, Larisa M Haupt, Rod A Lea, Maher K Gandhi and Lyn R Griffiths. BMC Genomics. 2014; 15(1): 390.

A comprehensive analysis of the cellular and EBV specific microRNAome in primary CNS PTLD identifies different patterns of EBV association. S. E. K. Fink; M. K. Gandhi; J. Nourse; C. Keane; K. Jones; P. Crooks; K. J A. Korfel; H. Schmidt; S. Neumann; A. Tiede; U. J U. D R. Neuhaus; M. Dreyling; K. Borchert; T. S H. Riess; I. Anagnostopoulos; R. U. Trappe. American Journal of Transplantation. 2014 Nov;14(11):2577 87

A Multi Centre, Single Arm, Open Label Study Evaluating the Safety and Efficacy of Fixed Dose Rituximab in Patients with Refractory, Relapsed or Chronic Idiopathic Thrombocytopenic Purpura (R ITP1000 Study). Huyen Tran, Tim Brighton, Andrew Grigg, Simon McRae, Joanna Dixon, Daniel Thurley, Maher K. Gandhi,Matt Truman, Paula Marlton, and John Catalano. British Journal of Haematology. 2014 Oct;167(2):243 51.

Plasma microRNA are disease response biomarkers in classical Hodgkin Lymphoma. Kimberley Jones, Jamie P. Nourse, Colm Keane, Atul Bhatnagar, and Maher K. Gandhi. Clinical Cancer Research. 2014 Jan 1;20(1):253 64.

A new frontier in haematology bvlgari fake gold ring combining pharmacokinetics with pharmacodynamic factors to improve choice and dose of drug. David Arpon, Maher K. Gandhi, Jenny Martin. British Journal of Clinical Pharmacology. 2014 Aug;78(2):274 81.

The presence of KIR2DS5 confers protection against adult immune thrombocytopenia. L A. Seymour, JP. Nourse, P Crooks, L Wockner, R Bird, H Tran MK. Gandhi. Tissue Antigens. Kimberley Jones, Louise Seymour, Maher K. Gandhi. Book Chapter "Biomarkers in Disease: Methods, Discoveries and Applications." Accepted 2014.

CD4+Tumor infiltrating lymphocytes are prognostic and independent of R IPI in patients with DLBCL receiving R CHOP chemo immunotherapy Keane, Colm, Gill, Devinder, Vari, Frank, Cross, Donna, Griffiths, Lynn and Gandhi, Maher (2013) American Journal of Hematology, 88 4: 273 276. (2013) Genes Chromosomes and Cancer, 52 5: 467 479. and Trappe R. (2013) American Journal of Transplantation, 13 6: 1512 1522.

The Epstein Barr Virus microRNA BART11 5p targets the early B cell transcription factor EBF1 Ross, Nathan, Gandhi, Maher K. and Nourse, Jamie P. (2013) American Journal of Blood Research, 3 3: 210 224.

Serum CD163 and TARC as Disease Response Biomarkers in Classical Hodgkin Lymphoma. Jones bulgari b zero fake ring KL, Vari F, Keane C, Crooks P, Nourse JP, Seymour LA, Gottlieb D, Ritchie DS, Gill D, Gandhi MK. Clin Cancer Res. 2013 Feb 1;19(3):731 42.

Back to basics: the complete blood cell count adds to the ability of immunohistochemistry in diffuse large B cell lymphoma prognosis Vari, Frank and Gandhi, Maher K. (2012) Leukemia Lymphoma, 53 11: 2097 2098.

Homozygous FCGR3A 158V alleles predispose to late onset neutropenia after CHOP R for diffuse large B cell lymphoma Keane, C., Nourse, J. P., Crooks, P., Nguyen Van, D., Mutsando, H., Mollee, P., Lea, R. A. and Gandhi, M. K. (2012) Internal Medicine Journal, 42 10: 1113 1119.

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